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HCSRN includes 20 research centers, each associated with a health care delivery system. Researchers at the centers collaborate on research networks and multi-site studies in real-world health care settings across the United States and in Israel. With health care systems serving more than 20 million individual patients, HCSRN can draw conclusions about how best to care for both common and rare health concerns. Network researchers have been answering pressing questions about keeping people healthy and delivering effective care since the network was formed in 1994.