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NIH Pragmatic Trials Collaboratory


NIH Pragmatic Trials Collaboratory is intended to improve the way clinical trials are conducted by creating a new infrastructure for collaborative research, and particularly pragmatic clinical trials. The ultimate goal is to ensure that healthcare providers and patients can make decisions based on the best available clinical evidence.

The NIH Pragmatic Trials Collaboratory also supports the design and rapid execution of several high-impact Pragmatic Clinical Trial Demonstration Projects that address questions of major public health importance and engage health care delivery systems in research partnerships. The NIH Pragmatic Trials Collaboratory includes a Coordinating Center that provides national leadership and technical expertise in all aspects of research with health care systems.


Quick Facts

Primary Investigator

Richard Hodes, MD (NIA)

Key Members, Projects, & Offerings

Coordinating Center Members

  • Duke Clinical Research Institute
  • Center for Medical Technology Policy
  • Harvard Pilgrim Health Care Institute (HCSRN member)
  • Group Health Research Institute (HCSRN member)
  • Johns Hopkins Berman Institute of Bioethics

Demonstration Projects

Several of the the NIH Pragmatic Trials Collaboratory demonstration projects are led by or partner with HCSRN research centers and health systems.

  • A Pragmatic Trial of Lumbar Image Reporting with Epidemiology (LIRE). Jerry Jarvik, MD, University of Washington. Partnering health systems: Group Health, Kaiser Permanente Northern California, Henry Ford Health System, and Mayo Clinic.
  • (PPACT). Lynn DeBar, PhD – The Center for Health Research – Northwest. Partnering health systems:  Kaiser Permanente Northwest, Georgia, and Hawaii.
  • Decreasing Bioburden to Reduce Healthcare-Associated Infections and Readmissions (ABATE). Susan Huang, MD – University of California – Irvine. Partnering health system: Hospital Corporation of America, and in collaboration with Harvard Pilgrim Health Care Institute.
  • Suicide Prevention Outreach Trial (SPOT). Gregory Simon, MD, MPH – Group Health Research Institute. Partnering health systems: Group Health Cooperative, HealthPartners, Kaiser Permanente Colorado, and University of Pittsburgh Medical Center.
  • Strategies and Opportunities to Stop Colon Cancer in Priority Populations (StopCRC). Gloria Coronado, PhD – The Center for Health Research – Northwest. Partnering health systems: Federally Qualified Health Center Clinics, with the Oregon Community Health Information Network (OCHIN)
  • Time to Reduce Mortality in End-Stage Renal Disease (TiME). Laura Dember, MD – University of Pennsylvania. Partnering dialysis provider organizations: Fresenius Medical Care North America, and DaVita.
  • Pragmatic Trial of Video Education in Nursing Homes (PROVEN). Susan Mitchell, MD, MPH; Angelo Volandes, MD, MPH; Vincent Mor, PhD – Brown University. Nursing home health system partners: Genesis, PruittHealth (492 nursing homes)
  • Improving Chronic Disease Management with Pieces (ICD-Pieces). Miguel Vazquez, MD – University of Texas Southwestern Medical Center. Partner health system: Parkland Health and Hospital System
  • Trauma Survivors Outcomes and Support (TSOS). Douglas Zatzick, MD – University of Washington School of Medicine. Health care partners: 24 Level I U.S. Trauma Centers
  • Nighttime Dosing of Anti-Hypertensive Medications (BPMedTime). Gary Rosenthal, MD – University of Iowa. Partnering academic medical centers: University of Iowa, and Duke University.

Select Key Offerings

  • Knowledge repository and The Living Textbook – The NIH Pragmatic Trials Collaboratory Coordinating Center offers collected documentation, guidance, and other resources on a variety of aspects of research with health systems.
  • Grand Rounds webinars– Join the The NIH Pragmatic Trials Collaboratory Coordinating Center for Friday “Grand Rounds” webinars or view archived webinars.